Prenatal stress decreasesBdnfexpression and increases methylation ofBdnfexon IV in rats
نویسندگان
چکیده
منابع مشابه
Effect of Prenatal Stress and Serotonin Depletion on Postnatal Serotonin Metabolism in Wistar Rats
Prenatal stress in rats results in structural, physiological and behavioral alterations that persist in adulthood. Serotonin (5-HT) is an important neurotransmitter known to be involved in these prenatal stress-induced behavioral alterations. The aim of the study was to investigate the effects of interrupted synthesis of 5-HT and immobilization stress during different gestational period on brai...
متن کاملPrenatal Stress Down-Regulates Reelin Expression by Methylation of Its Promoter and Induces Adult Behavioral Impairments in Rats
Prenatal stress causes predisposition to cognitive and emotional disturbances and is a risk factor towards the development of neuropsychiatric conditions like depression, bipolar disorders and schizophrenia. The extracellular protein Reelin, expressed by Cajal-Retzius cells during cortical development, plays critical roles on cortical lamination and synaptic maturation, and its deregulation has...
متن کاملPrenatal Caffeine Exposure Impairs Pregnancy in Rats
Background In recent years, concerns have been raised about human reproductive disorders. Caffeine consumption is increasing by the world’s population and there is a relationship between caffeine intake and adverse reproductive outcomes. The aim of this study was to evaluate the effects of caffeine on implantation sites, number of live births, birth weight, crown-rump length (CRL) and abnormali...
متن کاملPrenatal stress increased γ2 GABAA receptor subunit gene expression in hippocampus and potentiated pentylenetetrazol-induced seizure in rats
Objective(s): Stress during pregnancy is able to bring extensive effects on neurobehavioral development in offspring. The GABAergic system plays a pivotal role in neuronal excitability, which can be affected by prenatal stress (PS). This study aimed to evaluate impact of the PS on γ2 subunit of gamma-aminobutyric acid A (GABAA) receptor gene expression in the hippocamp...
متن کاملEffect of prenatal immobilization stress on sexual activity in male Wistar rats
Since the stress influences the biological processes, in the present study the effect of prenatal immobilization stress on the sexual activity of male rats was studied. Adult male and female Wistar rats (Pasteur Institute, Tehran) were copulated. After observing the vaginal plugs, pregnant rats were divided into control and two experimental groups. All groups were kept under the laboratory co...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Epigenetics
سال: 2013
ISSN: 1559-2294,1559-2308
DOI: 10.4161/epi.27558